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Cake day: June 20th, 2023

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  • I had Virgin Media broadband when I was a student from roughly 2013-2016. It was cheap because they were the only ISP at the time that didn’t bundle a phone line. It was unreliable, never hit advertised speeds and was throttled to all hell. The first time I called to cancel it, I discovered that their cancellation hotline (the only way to cancel) was offline for the entire day due to a ‘network upgrade’.

    Recently a Virgin media salesperson came to my house to promote their new fiber network and when I told him I had been a customer for 3 years and thought the service was terrible he said he didn’t want to hear about it.

    I wish them a very happy bankruptcy.



  • The usefulness of alphafold had been grossly overstated by science media. The structures it generates are mostly nonsense, they typically can’t generate molecular dynamics simulation trajectories with the correct physical properties, which makes them not useful for drug discovery. in computational biology today you’ll most often find them in use as a starting point for structure refinement or as one of many sources of data for some integrative method. Again, not useless, and an improvement over previous structure prediction algorithms, but they didn’t ‘solve protein folding’ or anything, like Google might have you believe. I don’t put much stock in Nobel prizes, I mean, they gave one to Henry Kissinger.

    Google also released alphafold 3 under a strict non commercial license, which severely limited its usefulness for both commercial and academic work, the latter of which all but requires using more permissive licenses. I assume Google wanted to monetize a commercial version of it at some point.

    I’ve been using Openfold 3 in some work I’ve been doing recently, and while the software is a bit undercooked, it does produce structures similar to alphafold 3 without any of Google’s bullshit. So I wouldn’t worry too much about this announcement. The protein folding will continue with or without them









  • the browser itself doesn’t matter. Google have had 10 years to do what they want with the specs for html, CSS and JavaScript, to define everything from browser extension APIs to the http protocol itself. they have won. not only have they spent a decade architecting the web in a way that mostly benefits them, they have made those specifications so bloated and complicated that nobody can develop a competitor from scratch. it took years to undo the damage wrought by ie6’s stagnation but this is different. this shit can’t be undone. it’s fucked forever


  • in my opinion the market is too segmented. Facebook took Oculus and refocused them onto standalone vr instead of pcvr, and secluded away a bunch of releases as Oculus exclusives. psvr is in a similar state. there isn’t enough vr software being made to support two separate walled gardens plus steamvr. in their rush to establish a vr monopoly, Facebook killed it. that’s my opinion

    I’ll be hanging onto my vive cosmos for occasional games of beat saber but I think vr at this point has become an expensive novelty